ACLY antibody - 100µg

ACLY Antibody is a high-specificity reagent targeting ATP Citrate Lyase (ACLY), a ~120 kDa cytosolic enzyme that catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate in an ATP-dependent manner. ACLY is a pivotal enzyme linking carbohydrate metabolism to lipid biosynthesis, playing a central role in de novo lipogenesis and histone acetylation through its generation of cytosolic acetyl-CoA. Expression and activity of ACLY are regulated by growth factors, insulin signaling, and oncogenic pathways (e.g., PI3K/AKT). ACLY antibodies are validated for applications including Western blotting, immunocytochemistry, immunohistochemistry, and immunoprecipitation, and are critical for investigating metabolic reprogramming in cancer, lipid metabolism disorders, and epigenetic regulation.